Fernanda Peñaloza (Alicia Rodriguez) gets the news he has cancer and vows to commit suicide. When you are about to jump off a bridge, Pancho Lopez (Arath de la Torre), a vegetable dealer, says that life is beautiful and we must fight for it every day. Persuades and invites her up to his truck, which was called 'La Burra'.
Fernanda knows Pancho's four children: Lupita (Ale Garcia) is the spoiled daughter, a lovely girl who inherited his father's love for social service. Anna (Sherlyn) is a music lover and has not realized that is pretty, sometimes feels that his father wants more for her Lupita. Temo (Daniel Arevalo) is the baby of the family, when he was born, Laura (Ana Barbara), Pancho's wife, died giving birth, was raised by Chela (Luz Elena Gonzalez), sister of Pancho, she took family when his sister died. Chela has a secret: his only love in life was Pancho.
Pepe Lopez (Pablo Lyle) is the eldest son of Pancho. It is bold, apprentice mechanic and pilot likes cars, and this relates to people of different social strata. Meet Monica Rinaldi (Violeta Isfel), rich girl and girlfriend of Freddy Irabia (Juan Diego Covarrubias) and become rivals, not only in racing but also in love for Monica.
Candelaria (Alicia Machado) is the sister of Pancho. She is beautiful and there is a diva, exposes its lush beauty for all to admire men in the neighborhood.
Pancho Lopez and his family face a serious problem: the neighborhood is foreclosed and no money to pay the debt, it hurts to Pancho is failing to protect his family.
Fernanda Peñaloza values honesty and responsibility of Pancho Lopez, considered an honest man, quite the opposite of his nephew Vicente Irabia (Sergio Sendel), a type convenenciero and ambitious, who longs for his aunt to die for her fortune and president of the company.
Enzzo Rinaldi (Pedro Moreno) wants to strip the Lopez family and friends from his neighborhood. Pancho is cornered, suffer humiliation with his family and has no choice but to accept the proposal of Fernanda Peñaloza and become president of the cosmetics company.
Rebeca Treviño (Mayrín Villanueva), beautiful and intelligent woman who advises Pancho in his role as president of the company. She will educate, teach him to behave and make determinations in the world of finance. Will become the rival of Chela.
The Lopez family moves into the mansion of Fernanda and will be neighbors of the family Irabia: Vicente, Pina (Daniel Castro) and Freddy. This change will bring fun situations among the poor and the rich.
Pina is the wife of Vincent, a hypochondriac woman because her husband is not paying attention and did not increase his child. It has a radio program, 'Pina Comment' that serves as therapy. Only accompanied by the dog? Bee? family pet. But later, 'Popeye', the current dog López seduces the fine dog, which causes a conflict between the families.
And following the footsteps of 'Bee', Vincent is captivated by the sensual beauty of the Candela and is given a torrid romance between them full of droll situations.
The two families, Lopez and Irabia intersect in a series of funny and exciting situations where Anne, who hates the shallowness, falls just a superficial guy, Freddy. And know the passion Pina Thomas (Osvaldo de Leon), Lupita's boyfriend, whom she unleashed exciting situations, giving Pena a fire back into your life.
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